Microbubble-enhanced ultrasound stimulation of β-cells improves insulin release and glycemic control in mice.

ABSTRACT: Diabetes poses a significant global health burden, with complications such as cardiovascular disease, stroke, and kidney failure. While insulin therapy is central to type 2 diabetes (T2D) management, its limitations-including rapid degradation and the need for frequent injections-highlight the demand for non-invasive alternatives. Here, we present an ultrasound (US)-mediated approach to enhance insulin release by selectively stimulating pancreatic β-cells via targeted microbubbles (MBs). In vitro experiments using RINm5F β-cells demonstrated that US-MB stimulation induces significant calcium influx and subsequent insulin release. In addition, this method effectively decreased blood glucose levels in mice by promoting insulin release. Mechanistic studies revealed that mechanosensitive ion c

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12836977 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature