Melanoma antigen genes A1 and A3 as predictors of treatment response and survival in HCV-associated hepatocellular carcinoma: a prospective study.

ABSTRACT:

Introduction

Hepatocellular carcinoma (HCC) accounts for approximately 90% of all primary liver cancers resulting in approximately 830,000 deaths in 2020, making HCC the sixth most common cancer globally. Several members of the Melanoma Antigen Gene (MAGE) family, such as MAGE-A1 and A3 genes of the MAGE I-A subfamily, are abnormally expressed in a variety of cancers including melanomas, colorectal cancer, non-small cell lung cancer, gliomas, HCC, prostate, and breast cancers. In addition, they have been linked to tumor stemness and, therefore, may predict therapeutic response and prognosis.

Aim of the study

To investigate the expression pattern of MAGE-A1 and A3 genes in HCC patients and to evaluate their prognostic value.

Subjects and methods

This prospective four-y

SUBMITTER: Elgamal H 

PROVIDER: S-EPMC12836994 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature