Esketamine relieves postoperative depression and pain indicators in patients undergoing laparoscopic total hysterectomy.

ABSTRACT:

Objective

This study aimed to investigate the effects of perioperative esketamine on postoperative depression and pain in patients undergoing laparoscopic total hysterectomy.

Methods

135 patients undegoing laparoscopic total hysterectomy were recruited and randomly allocated to three groups. Finally, a total of 127 patients were selected into the statistical analysis, with the final grouping information as follows: sufentanil group (S1, n = 44), sufentanil combined with 0.25 mg/kg esketamine group (SK1, n = 42) and sufentanil combined with 0.5 mg/kg esketamine group (SK2,n = 41) intraoperatively, then postoperative analgesia was maintained with sufentanil (2 µg/kg) via patient-controlled intravenous analgesia (PCIA) in all groups, while a 1 mg/kg dose of esketamine was added

SUBMITTER: Jing J 

PROVIDER: S-EPMC12837023 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature