Research progress of 3D-printed PLGA scaffolds for the treatment of bone defects.

ABSTRACT: With rapid advances in regenerative medicine and tissue engineering, poly(lactic-co-glycolic acid) (PLGA) scaffolds have garnered extensive attention owing to their excellent biocompatibility and biodegradability. Current studies primarily focus on material selection and scaffold preparation, printing techniques, and their efficacy in animal experiments and clinical applications. While several studies have demonstrated the potential of PLGA scaffolds in promoting bone regeneration, challenges remain, including insufficient mechanical properties, a mismatch between degradation rates and bone repair rates, limited long-term clinical data, and the need for improved hydrophilicity and cytocompatibility. Additionally, issues such as limited printing precision and resolution persist. Therefore,

SUBMITTER: Yang H 

PROVIDER: S-EPMC12837045 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature