Curation of the Fasciola hepatica kinome as a resource for drug target discovery.

ABSTRACT:

Background

Fascioliasis is a zoonosis and neglected tropical disease with worldwide distribution and significant economic impact. The search for anthelmintic compounds against Fasciola hepatica, one of the parasitic liver flukes responsible for this disease, has become important due to widespread resistances against existing drugs. To facilitate drug discovery, a useful strategy is the identification of proteins that are vital for the parasite. Protein kinases (PKs) emerged as potential targets in several parasites, given their critical role in many biological processes. To date, knowledge of the PKs present in F. hepatica is fragmentary.

Results

We curated and classified the kinome of F. hepatica using a refined bioinformatics pipeline and found 245 PKs, which represented 2

SUBMITTER: Ajmera S 

PROVIDER: S-EPMC12837073 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature