Conductive hydrogel combined with electrical stimulation remodels the microenvironment for nerve regeneration to promote spinal cord injury repair.

ABSTRACT: The secondary inflammatory response and disruption of electrical signaling following spinal cord injury (SCI) present significant challenges to neurological recovery. Modulating the inflammatory microenvironment and reconstructing the spinal cord's electrophysiological network are essential for effective SCI repair. To address these challenges, we designed a biomimetic 3D soft scaffold composed of phenylboronic acid-modified sodium alginate(Alg-PBA), dopamine-modified methacrylated gelatin(GelMA-DA), and Zn@EGCG modified MXene. This scaffold demonstrated excellent injectability, with an elastic modulus and electrical conductivity that closely matched those of native spinal cord tissue. The release of Zn@EGCG from the scaffold effectively suppressed inflammatory factors, promoted macrophage

SUBMITTER: Du H 

PROVIDER: S-EPMC12837084 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature