Engineering chitosan fibers with MSC-exosome cargo: a clinically translatable multifunctional dressing for regenerative therapy in infected wound management.

ABSTRACT:

Background

Chronic wound healing is a complex clinical challenge, particularly due to microbial colonization and the deactivation of repair cells. This study presents an innovative strategy involving the combination of micron-scale chitosan fibers with exosomes, aiming to develop a new type of dressing with multiple functionalities, including dynamic exudate management, antimicrobial properties, angiogenesis promotion, and tissue repair. The goal is to offer a cost-effective and clinically translatable treatment solution for infected wounds.

Methods

Chitosan (CS) fibers were prepared using a wet-spinning technique and subsequently modified through N-succinylation (NCS), followed by needle-punching to construct CS/NCS blended nonwoven fabrics. The physicochemical properties,

SUBMITTER: Gao J 

PROVIDER: S-EPMC12837088 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature