Systematic review and meta-analysis of humoral immunity proteins and mortality in sepsis.

ABSTRACT:

Purpose

Humoral immunity proteins-immunoglobulins, complement proteins, and antimicrobial peptides-have key antimicrobial and immunomodulatory functions in sepsis. We hypothesised that their circulating levels are lower in non-survivors, potentially resulting in impaired bacterial clearance and persistent or recurrent infections.

Methods

We performed a systematic review and meta-analysis evaluating differences in humoral immunity proteins between survivors and non-survivors in adult patients with sepsis. PubMed and Embase were searched without date restrictions. Random-effects meta-analyses were used to estimate pooled standardised mean differences (SMD) with 95% confidence intervals (CI). Sensitivity analyses included data from the MIMIC-IV ICU database, and further supplem

SUBMITTER: Villa A 

PROVIDER: S-EPMC12837105 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature