Influence of caloric restriction history, intermittent exposure to palatable food and sex in a binge eating model in C57BL/6J mice.

ABSTRACT:

Background

Several animal protocols have been designed to model binge eating disorder (BED) and elucidate its neurological basis. A wide variety of factors, including the frequency of access to palatable food and a previous history of caloric restriction, have been modulated to induce binge eating intake. The aims of this work were to compare the effects of these two factors on the development of binge eating behaviour and to analyse possible alterations in neurotransmitter markers in the striatum.

Methods

We performed a binge eating test in male and female C57BL/6J mice, which consisted of 2 h of limited access to a high-fat high-sucrose (HFHS) diet in a sated state with ad libitum access to a control diet and water. Mice were subjected to either daily or intermittent (ever

SUBMITTER: Morales-Puerto N 

PROVIDER: S-EPMC12837107 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature