Deep immunophenotyping in aneurysmal subarachnoid hemorrhage: a prospective and controlled clinical study.

ABSTRACT:

Background

Aneurysmal subarachnoid hemorrhage (aSAH) remains a devastating cerebrovascular condition with significant morbidity and mortality. While inflammation plays a critical role in post-hemorrhagic complications, the specific polarization dynamics of monocyte and T cell subpopulations in this context remain poorly understood. This study aims to investigate these immune cell shifts and their correlation with major complications such as angiographic cerebral vasospasm and delayed cerebral ischemia (DCI).

Methods

We conducted a prospective, controlled observational single-center cohort study in a neurovascular university center of maximum care in Germany. A total of 75 patients with aSAH and 20 healthy controls were included. Blood samples were collected on days 1, 4, 7,

SUBMITTER: Hofmann BB 

PROVIDER: S-EPMC12837136 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature