Soft Interferometric Nanostrain Sensor Reveals Solid-Liquid Interfacial Tension Oscillation Amplified by Competitive Adsorption.

ABSTRACT: Understanding the adsorption of protein mixtures is significant for engineering biosurface functionalities that affect biomaterial hemocompatibility and infections over medical instruments. However, existing methods cannot detect real-time competitive adsorption events or require fluorophore labelling that may alter the adsorption characteristics. An interferometric nanostrain sensor has been developed to investigate real-time adsorption of unlabeled proteins. The sensor exploits the elastocapillary effect on the substrate nanometer deformation by a sessile protein drop to measure instantaneous interfacial tensions at its three-phase contact line. Using fetal bovine serum (FBS), it is shown that asymptotically, the solid-liquid interfacial tension (γ_SL) decreases with increasing

SUBMITTER: Cheng SKS 

PROVIDER: S-EPMC12837351 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature