Surgery versus stereotactic body radiotherapy for oligometastatic colorectal cancer: a prospective cohort study with propensity score matching.

ABSTRACT:

Background

The optimal local therapy for oligometastatic colorectal cancer (CRC) remains undefined, with radical surgical resection and stereotactic body radiotherapy (SBRT) serving as the primary modalities. High-quality comparative evidence is scarce. This study aimed to prospectively compare overall survival (OS), local tumor control (LTC), quality of life (QoL), adverse events, and healthcare resource utilization between these two treatments.

Methods

In this prospective, observational cohort study, 478 patients with 1-3 oligometastases from CRC were enrolled. Treatment assignment was determined by a multidisciplinary tumor board. Propensity score matching (PSM) was used to adjust for baseline imbalances, creating 152 well-balanced pairs (n = 304) for analysis. The primar

SUBMITTER: Wang D 

PROVIDER: S-EPMC12837356 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature