Integrated Transcriptomic and Proteomic Analysis of the Stress Response Mechanisms of Micractinium from the Tibetan Plateau Under Leather Wastewater Exposure.

ABSTRACT: In this study, a strain of green microalga adapted to the extreme environmental conditions of the Tibetan Plateau was isolated from the Lalu Wetland. The isolate was identified and tentatively designated as Micractinium sp. LL-1. Following the inoculation of strain LL-1 into tannery wastewater, the ammonia nitrogen concentration was rapidly reduced, achieving a removal efficiency of 98.7%. The maximum accumulated biomass reached 1641.68 mg/L and 1461.28 mg/L. Integrated transcriptomic and label-free quantitative proteomic approaches were employed to systematically investigate the molecular response mechanisms of LL-1 under tannery wastewater stress. Transcriptomic analysis revealed that differentially expressed genes were enriched in pathways related to cell proliferation, morphogen

SUBMITTER: Wang H 

PROVIDER: S-EPMC12837426 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature