The association of frailty and mechanical power with hospital mortality in critically ill patients: a retrospective study based on the MIMIC-IV and eICU database.

ABSTRACT:

Background

Frailty, characterized by diminished physiological reserve, and high mechanical power are well-established risk factors for mortality in critically ill patients. However, the potential synergistic impact of these two factors on clinical outcomes remains insufficiently explored.

Methods

Baseline data from critically ill patients were extracted from the MIMIC-IV and eICU-CRD databases. Frailty was evaluated using the Laboratory-based Frailty Index (FI-Lab), and mechanical ventilation intensity was quantified by mechanical power (MP). Generalized linear mixed models (GLMMs) and logistic regression analyses were employed to assess the associations between FI-Lab, MP, their interaction, and hospital mortality.

Results

A total of 17,881 critically ill patients we

SUBMITTER: Shen J 

PROVIDER: S-EPMC12837449 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature