A Neutral Polysaccharide from Ginseng Berry Mitigates D-Galactose-Induced Oxidative Stress and Cognitive Deficits Through the Keap1/Nrf2/HO-1/NQO1 Pathway.

ABSTRACT: Oxidative stress contributes to brain aging processes and is implicated in related functional decline. Developing strategies to mitigate oxidative stress is therefore of significant interest. In this study, a neutral polysaccharide (GBPN) was isolated from ginseng berry. Structural analysis revealed that GBPN (molecular weight 1.52 × 10⁴ Da) is primarily composed of glucose (53.18%), arabinose (24.3%), and galactose (16.75%). Glucose exists in the forms of →4)-Glcp-(1→ (32.95%), →6)-Glcp-(1→ (13.81%), and →4,6)-Glcp-(1→ (3.70%), while arabinose exists as →1)-Araf (9.73%), →1)-Arap (5.82%), →2)-Arap-(1→ (0.66%), →5)-Araf-(1→ (7.62%), and →3,5)-Araf-(1→ (1.69%) forms, while galactose exists in the forms of →1)-Galp (3.

SUBMITTER: Ren T 

PROVIDER: S-EPMC12837864 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature