A Systematic Review of the Current Evidence of the Effectiveness and Safety of Immunoprophylaxis Using Sublingual Dead Whole Bacteria to Prevent Recurrent Urinary Tract Infections (rUTIs).

ABSTRACT: Background/Objectives: Recurrent urinary tract infections (rUTIs) remain a major clinical challenge, but sublingual immunoprophylaxis with inactivated whole bacteria is a promising alternative to antibiotic prophylaxis. The objective of this systematic review was to assess the efficacy and safety of sublingual bacterial vaccines. Methods: We searched MEDLINE, Cochrane CENTRAL, and Embase (January 1979-August 2025) for English-language studies evaluating bacterial vaccines for rUTI prevention. Eligible studies included adults receiving sublingual immunoprophylaxis with heat-inactivated whole bacteria. Outcomes were UTI recurrence, infection-free interval, and adverse events. Both MV140 and autovaccines were assessed. Results: Of the 262 records identified, 14 studies me

SUBMITTER: Medina-Polo J 

PROVIDER: S-EPMC12837869 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature