Complete gene sequence diversity, amplification, and natural selection of the Plasmodium vivax Duffy binding protein locus.

ABSTRACT:

Background

The Duffy binding ligand domain of Plasmodium vivax (PvDBPII) interacts with Duffy blood-group antigen on the surface of reticulocytes during host cell invasion process. Although diversity of this domain has been analysed among worldwide isolates, the evolution of the complete PvDBP gene remains to be explored.

Methods

In total, 232 P. vivax isolates from northwestern, northeastern, eastern, and southern Thailand were included for analyses of the complete gene sequence, copy number variation and duplication genotypes of Pvdbp. The Duffy blood-group genotypes of the patient were also determined.

Results

Pvdbp duplication, all of the Cambodian type, was detected in 22 isolates (9.48%), characterized by identical copies (n = 17) and microheterogeneity between

SUBMITTER: Putaporntip C 

PROVIDER: S-EPMC12837903 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature