Genomic Evidence Supporting a One Health Perspective on Staphylococcus aureus Bovine Mastitis.

ABSTRACT: Background/Objectives:Staphylococcus aureus is a multifaceted pathogen responsible for diseases in humans and in several animal species, including dairy cows. This study aimed to characterize and compare the genetic diversity, lineage distribution, and antimicrobial resistance profiles of S. aureus isolates from bovine milk with human-derived reference genomes to investigate host adaptation and inter-species transmission. Methods: Genomic analyses were performed on S. aureus isolates from quarter milk samples of dairy cows together with human-derived sequences from public databases. Whole-genome sequencing and multi-locus sequence typing (MLST) were used to determine sequence type (ST) distribution, and the presence of key antibiotic resistance genes and

SUBMITTER: Meroni G 

PROVIDER: S-EPMC12837917 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature