Isolation, Characterization, and Evaluation of a Lytic Jumbo Phage Z90 Against Aeromonas hydrophila in American Eels (Anguilla rostrata).

ABSTRACT: Background:Aeromonas hydrophila is a common bacterial pathogen that causes hemorrhagic septicaemia in several farmed aquaculture species. Phage therapy is considered a promising and feasible alternative to antibiotic treatment. Methods: In this study, an A. hydrophila-infecting jumbo phage Z90 was isolated from an aquaculture pond. The biological characteristics, genomic features, and in vitro and in vivo experiments were investigated to evaluate its application potential. Results: Phage Z90 was a myovirus with distinctive curled tail fibers. Additionally, phylogenetic and genomic analyses found that the phage Z90 was a novel virus belonging to the genus Ferozepurvirus of the family Chimalliviridae. One-step growth curve analysis revealed th

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12837969 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature