Dose- and Time-Dependent Modulation of Cx43 and Cx45 Expression and Gap Junction Conductance by Resveratrol.

ABSTRACT: Plant extracts are rich in various bioactive compounds, such as polyphenols, flavonoids, tannins, terpenoids, phenolic acids, saponins, alkaloids, and polysaccharides. Antioxidant polyphenols are increasingly attracting attention, not only as dietary components but also as valuable food industry byproducts. Resveratrol, present in a wide range of plants, is well recognized for its diverse biological activities, including antioxidant, antitumor, cardioprotective, and neuroprotective effects. Given the importance of intercellular communication in these physiological processes, gap junctions (GJs) composed of connexin (Cx) family proteins are of particular interest because they provide a direct pathway for electrical and metabolic signaling and are key players in maintaining normal organ func

SUBMITTER: Janciuke G 

PROVIDER: S-EPMC12838047 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature