PLAAT2 facilitates the development of pancreatic cancer and serves as a predictor of resistance to chemotherapy.

ABSTRACT:

Background

Pancreatic cancer (PC) remains one of the deadliest human malignancies, and reliable biomarkers for prognosis and therapeutic stratification are still lacking. PLAAT2 (phospholipase A and acyltransferase 2), an enzyme linked to lipid metabolism, has been implicated in metabolic regulation, but its role in PC is not fully defined.

Methods

Transcriptomic profiles from TCGA-PAAD and independent GEO datasets, together with the corresponding clinical annotations, were analysed to clarify the prognostic relevance and biological roles of PLAAT2. Functional enrichment, immune-cell infiltration, mutational profiles and predicted drug responses were analyzed, and a PLAAT2-related prognostic signature was generated by LASSO-Cox analysis and validated in external GEO datasets

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12838068 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature