Utility of Dynamic ⁶⁸Ga-DAZA-PET/CT for Bile Leak Localization After Liver Transplantation: First Clinical Experiences.

ABSTRACT: Background/Objectives: Biliary complications are common after liver transplantation (LT), with bile leaks representing a major cause of morbidity. Conventional imaging modalities such as ultrasound, CT, MRCP, and endoscopic techniques may fail to localize peripheral or complex leaks. This study aimed to evaluate the feasibility of [⁶⁸Ga]Ga-TEoS-DAZA-PET/CT for non-invasive localization of bile leaks after LT. Methods: Five male patients (mean age 53.2 years) with suspected bile leakage and inconclusive prior imaging underwent [⁶⁸Ga]Ga-TEoS-DAZA-PET/CT. The tracer was synthesized under GMP conditions and administered at a mean activity of 204 ± 42 MBq. Dynamic PET/CT imaging was performed for 60 min, and findings were classified according to the Nagano cl

SUBMITTER: Werner A 

PROVIDER: S-EPMC12838145 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature