Mitochondrial Dysfunction Combined with Elevated CoQ₁₀ Levels Specifically in Placental Cytotrophoblasts Suggests a Role for Mitophagy in Preeclampsia.

ABSTRACT: Preeclampsia is a serious pregnancy disorder of unknown etiology. One of its cellular hallmarks is increased mitochondrial dysfunction in placental tissue. Further investigation into this aspect may help elucidate the molecular basis of preeclampsia. A total of 24 pregnant women who delivered by cesarean section participated in the study: n = 13 controls and n = 11 diagnosed with preeclampsia. Maternal blood samples were collected to assess the biochemical profile, and demographic and clinical data were recorded. Placental trophoblast samples were processed to isolate mitochondria and perform molecular biology assays. Women with preeclampsia exhibited the characteristic clinical features of the disease, along with biochemical alterations consistent with an inflammatory proces

SUBMITTER: Abalos-Martinez J 

PROVIDER: S-EPMC12838238 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature