Discovery of MBL-AB01: a novel antibacterial xanthone antibiotic with high activity against methicillin-resistant <i>Staphylococcus aureus</i>.

ABSTRACT: A novel compound denoted MBL-AB01 was isolated from a marine Actinoalloteichus, which belongs to a rare and underexplored class of Actinobacteria. This work demonstrates that the novel compound MBL-AB01 shows very high activity in vitro against six methicillin-resistant Staphylococcus aureus strains, and high activity against a panel of three other Gram-positive strains, including a vancomycin-resistant Enterococcus faecium. Structure elucidation of the compound revealed that MBL-AB01 is a polycyclic xanthone antibiotic closely related to the bioactive compounds: xantholipin and lysolipin. This class of antibiotics has caught interest due to its unique chemical structure and diverse biological activity. The gene cluster encoding MBL-AB01 production was id

SUBMITTER: Degnes KF 

PROVIDER: S-EPMC12838262 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature