Sex-Specific Differences in Gut Microbiota Composition in Adult Patients with Bronchial Asthma.

ABSTRACT: Background: Gut microbiota dysbiosis has been associated with childhood asthma; however, its role in adult bronchial asthma (BA), particularly in Japanese populations, remains unclear. The potential influence of sex-based differences also warrants investigation. We aimed to investigate the association between gut microbiota composition and adult BA in a Japanese cohort, focusing on sex-specific differences. Methods: Stool samples from 108 Japanese adults with BA (48 male and 60 female individuals) and 210 healthy controls (90 male and 120 female individuals) were analyzed using 16S rRNA gene sequencing. Analyses were stratified by sex. β-diversity was assessed using non-metric multidimensional scaling and permutational multivariate analysis of variance. Genus-level taxonomic

SUBMITTER: Hirano C 

PROVIDER: S-EPMC12838268 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature