An Unexpected Inverse Relationship Between Biofilm Formation and Antibiotic Resistance in Stenotrophomonas maltophilia.

ABSTRACT: Background/Objectives: Stenotrophomonas maltophilia is an opportunistic pathogen causing severe infections, particularly in patients with cystic fibrosis (CF). Its intrinsic multidrug resistance and biofilm-forming capacity complicate treatment. Although biofilms are generally associated with antimicrobial tolerance, the relationship between biofilm formation and planktonic antibiotic resistance in S. maltophilia remains poorly understood. This study investigated the association between antibiotic resistance profiles and biofilm production in clinical isolates from CF and non-CF patients. Methods: A total of 86 clinical isolates (40 from CF airways and 46 from non-CF patients) were analyzed. Susceptibility to seven antibiotics was assessed by disk diffusion, and

SUBMITTER: Pompilio A 

PROVIDER: S-EPMC12838282 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature