Tetracycline Resistance Among Canine Methicillin-Resistant Staphylococcus pseudintermedius (MRSP) Clinical Isolates: Is Minocycline a Viable Treatment Option?

ABSTRACT: Background/Objectives: Infections caused by multidrug-resistant methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains are becoming increasingly common in veterinary medicine. Depending on which tet genes are present, MRSP isolates may exhibit resistance to all tetracyclines or resistance to tetracycline and doxycycline with susceptibility to minocycline. As minocycline may be a potential treatment option, our study aimed to verify this hypothesis. We have compared phenotypic resistance to tetracyclines with the presence of the tet(K), tet(L), tet(M), and tet(O) genes and conducted the molecular characterization of 50 clinical MRSP isolates of canine origin. Methods: The presence of the tet genes was determined by

SUBMITTER: Kizerwetter-Swida M 

PROVIDER: S-EPMC12838334 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature