<i>N</i>-benzyl-<i>N</i>-methyldithiocarbamate (BMDC) combines with metals to produce antimicrobial and anti-biofilm activity against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and <i>Staphylococcus epidermidis</i>.

ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) is a high-priority microorganism that necessitates the development of new treatments, as it causes a substantial disease burden and economic impact globally. MRSA colonizes the skin and anterior nares and can potentially become invasive, leading to pneumonia and soft tissue infection. Additionally, MRSA can establish chronic infections in wounds and medical implants, partly due to its ability to form biofilms. Likewise, the skin commensal Staphylococcus epidermidis also causes similar infections, particularly through its ability to form a plastic-binding biofilm. In this study, we used N-benzyl-N-methyldithiocarbamate (BMDC) in combination with copper or zinc to decrease the viability of MRSA in both planktonic

SUBMITTER: Sanchez-Rosario Y 

PROVIDER: S-EPMC12838442 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature