Non-suicidal self-injury links with multidimensional cognitive dysfunctions in adolescents with depression.

ABSTRACT:

Background

Non-suicidal self-injury (NSSI) has high prevalence among adolescents with mood disorders and is accompanied by cognitive impairments. Most existing studies have examined their impairments on single cognitive domains. It remains unclear which cognitive deficits are associated with adolescent NSSI and its functions and addictive features, from a multidimensional perspective.

Methods

A total of 161 adolescents diagnosed with first-episode major depressive disorder (MDD) and 137 healthy controls were recruited between June 2020 and December 2024. Participants were divided into three groups: adolescents with MDD and NSSI (MDD + NSSI, n = 84, age = 15.47 ± 1.59), those with MDD and without NSSI (MDD-NSSI, n = 77, age = 16.11 ± 2.16), and healthy controls (HCs, n = 137,

SUBMITTER: Li S 

PROVIDER: S-EPMC12838459 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature