Global trends in biomarker research for periprosthetic joint infection: a bibliometric analysis.

ABSTRACT:

Background

Periprosthetic joint infection (PJI) remains a major diagnostic challenge, and no single biomarker provides definitive accuracy. With rapid advances in synovial, serum, and molecular assays, a comprehensive overview of global biomarker research is needed. This study provides a broad, data-driven mapping of PJI biomarker research, clarifying major thematic shifts and their implications for clinical translation.

Methods

A literature search of the Web of Science Core Collection (2011-2024) identified research and review articles on PJI diagnostics and biomarkers. Bibliometric indicators, collaboration networks, and keyword co-occurrence were analyzed using VOSviewer, CiteSpace, and Bibliometrix. Co-citation and keyword analyses were used to determine influential refe

SUBMITTER: Li B 

PROVIDER: S-EPMC12838467 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature