Very long-chain saturated fatty acids in plasma lipids: association with cardiometabolic risk influenced by lipid interactions.

ABSTRACT:

Background

Very long-chain saturated fatty acids (VLCSFA) may influence cardiometabolic health differently from other, often detrimental, saturated fatty acids (SFA). Evidence remains inconclusive, partly because VLCSFA are metabolically derived from SFA, making it difficult to disentangle their individual effects due to potential confounding of correlated lipids. Prior studies rarely accounted for correlations with other lipids or do not consider VLCSFA-specific lipid classes. We investigated prospective associations of circulating VLCSFA (C20:0, C22:0, C24:0) across multiple plasma lipid classes with type 2 diabetes (T2D) and cardiovascular disease (CVD), accounting for confounding by correlated lipids.

Methods

We constructed two nested case-cohort studies within the Europ

SUBMITTER: Dominguez-Lopez I 

PROVIDER: S-EPMC12838474 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature