PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation.

ABSTRACT:

Background

Microplastics (MPs) have emerged as significant environmental pollutants, posing a threat to ecosystems and humans. The presence of MPs in atherosclerotic plaques, exacerbating cardiovascular risk, has been recently reported. However, the molecular mechanism underlying the effects of MPs on the vascular endothelium are still undefined. In this regard, this study aims to investigate the effects of MPs on endothelial cell function and redox state and the underlying mechanisms.

Methods

Immortalized human aortic endothelial cells (teloHAEC), human umbilical vein endothelial cells (HUVEC), and human coronary artery endothelial cells (HCAEC) were treated with MPs in the form of polyethylene (PE) and polyvinyl chloride (PVC) alone (70 µg/mL) or combined PE (30 µg/mL) + P

SUBMITTER: D'Onofrio N 

PROVIDER: S-EPMC12838487 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature