Synergistic Effects of Silica Nanoparticles, Chitosan and Bacillus velezensis AAHM-BV2301 on the Growth, Immunity, Gut Microbiota and Disease Resistance of Asian Seabass (Lates calcarifer).

ABSTRACT: In this study, the synergistic effects of dietary Bacillus velezensis AAHM-BV2301, silica nanoparticles (SiNPs), and chitosan (CS) on the growth performance, innate immunity, gut microbiota, and disease resistance of Asian seabass (Lates calcarifer) fingerlings were evaluated. A total of 400 fish (11.25 ± 2.12 g) were assigned to five dietary treatments for 30 days: control, BV (1 × 10⁸ CFU/kg feed), BVSiNP (1 × 10⁸ CFU/kg + 2 mg SiNP/kg), BVCS (1 × 10⁸ CFU/kg + 15 g CS/kg), and BVSiNPCS (combined additives at the same concentrations). The growth indices (WG, SGR, RGR, and FCR) significantly increased in the fish fed BVSiNPs, whereas the level of innate immunity increased across all the supplemented groups, with BVCS and BVSiNPCS having the st

SUBMITTER: Tangal JK 

PROVIDER: S-EPMC12838700 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature