Structural and Functional Neuroimaging Biomarkers as Predictors of Psychosis Conversion in Ultra-High Risk Individuals: A Systematic Review.

ABSTRACT:

Background

Approximately 20-30% of ultra-high risk (UHR) individuals transition to psychosis within 2-3 years. Neurobiological markers predicting conversion remain critical for precision prevention strategies.

Objective

To systematically identify and evaluate structural and functional neuroimaging biomarkers at UHR baseline that predict subsequent conversion to psychosis.

Methods

Following PRISMA 2020 guidelines, we searched five databases from January 2000 to February 2025. Two independent reviewers screened studies and assessed quality using the Newcastle-Ottawa Scale. Eligible studies examined baseline neuroimaging measures (structural MRI, functional MRI, diffusion tensor imaging, magnetic resonance spectroscopy) as predictors of psychosis conversion in UHR cohort

SUBMITTER: Martinotti G 

PROVIDER: S-EPMC12838713 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature