Subtype-Specific Brain Atrophy and White Matter Alterations in Mild Cognitive Impairment.

ABSTRACT: Background/Objectives: Identifying pathological distinctions among mild cognitive impairment (MCI) subtypes is important for differentiating dementia. The purpose of this study is to investigate subtype-specific structural alterations in amnestic MCI (aMCI) and non-amnestic MCI (naMCI) and evaluate their potential as imaging biomarkers for subtype classification. Methods: T1 and DTI MRI data from two independent cohorts were analyzed, including a discovery dataset (58 aMCI, 35 naMCI, and 95 NC) and a replication dataset (61 aMCI, 39 naMCI, and 67 NC). Surface-based morphometry and automated fiber quantification (AFQ) were used to examine cortical thickness and white matter microstructure. Mediation models were used to explore the links between brain structure and cognitive ou

SUBMITTER: Wei L 

PROVIDER: S-EPMC12838734 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature