Cocaine craving and use during pharmacotherapy trials for cocaine use disorder: A multi-trajectory analysis.

ABSTRACT:

Background

There is limited research on the course of drug craving in treatment trials of stimulant use disorders. This study examined trajectories of cocaine craving and use and their associations with other outcomes of cocaine use disorder in pharmacotherapy trials of cocaine use disorder.

Methods

In 1070 participants from 6 randomized controlled trials testing selegiline, baclofen, cabergoline, modafinil, reserpine, and tiagabine, we used multi-trajectory modeling to identify joint trajectories of weekly-measured cocaine craving and use. Association of these trajectories with Addiction Severity Index (ASI) health and social outcomes was assessed.

Results

A 3-trajectory model with High craving/High use (40.0 %), Decreasing craving/High use (36.8 %), and Decreasing c

SUBMITTER: Mojtabai R 

PROVIDER: S-EPMC12838864 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature