Combinatorial Analysis of CD4⁺Tregs, CD8⁺Teffs, and Inflammatory Indices Predict Response to ICI in ES-SCLC Patients.

ABSTRACT: Background: Small-cell lung cancer (SCLC) is an aggressive type of lung cancer, and several factors are currently used to predict poor outcomes, including performance status (PS), extensive-stage disease, male sex, advanced age, and elevated lactate dehydrogenase (LDH) levels. In this study, we aimed to explore the role of Tegs and inflammatory indices, such as CRP and NLR, in predicting response to immunotherapy. Methods: Fifty-one therapy-naïve ES-SCLC patients and ten healthy donors were enrolled. Peripheral blood mononuclear cells (PBMCs) were isolated and stained with fluorochrome-conjugated monoclonal antibodies. Multicolor flow cytometry was performed to determine the levels of CD8⁺ T cells and CD4⁺ Tregs, as well as their correlation with inflamm

SUBMITTER: Xagara A 

PROVIDER: S-EPMC12838880 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature