Dedifferentiation of Mature Adipocytes and Their Future Potential for Regenerative Medicine Applications.

ABSTRACT: Background/Objectives: Mature adipocytes were previously regarded as terminally differentiated cells that are restricted to lipid storage. Recent studies have shown that they can dedifferentiate into fibroblast-like progenitor cells, termed dedifferentiated fat (DFAT) cells. These cells exhibit stem cell-like properties and multilineage potential, highlighting their promising role in regenerative medicine and disease pathology. This systematic review aims to explore and consolidate the evidence regarding mechanisms, culture methods, pathophysiological roles, and therapeutic potential of adipocyte dedifferentiation. Methods: A systematic review was conducted in PubMed using the terms "dedifferentiation", "de-differentiation", "transdifferentiation", and related variants in com

SUBMITTER: Bayulgen DS 

PROVIDER: S-EPMC12838972 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature