Opn3 Drives Blue-Light-Induced Reduction in Lipid Droplets and Antiviral Defense.

ABSTRACT: Abnormal lipid metabolism is a key feature of many diseases. Therefore, investigating its underlying mechanisms is of great importance. Recently, blue light has shown promise as a drug-free way to influence energy metabolism, relying on the light-sensitive protein Opsin 3 (Opn3). This study aimed to investigate the effects of blue light irradiation on lipid droplet degradation in cells and its molecular mechanism, while also evaluating its potential antiviral effects. The results demonstrate that exposure to 470-480 nm blue light significantly reduced oleic-acid-induced intracellular lipid droplet accumulation and decreased triglyceride and total cholesterol levels, an effect dependent on the Opn3. It was found that blue light affects the Pparα signaling pathway through Opn3, and, at the s

SUBMITTER: Wu Q 

PROVIDER: S-EPMC12838999 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature