Prognostic Value of Phosphatidylinositol-3 Kinase p110 α Protein Expression in Patients with Stage I-III Invasive Breast Cancer.

ABSTRACT:

Background

The prognostic value of phosphatidylinositol-3-kinase p110α, a key catalytic subunit in the PI3K/AKT pathway, in breast cancer remains controversial. This study evaluated its prognostic significance in stage I-III invasive breast cancer.

Methods

p110α protein expression was detected via immunohistochemistry (IHC) in 161 patient tissue samples. Its association with overall survival (OS) and relapse-free survival (RFS) was analyzed using Kaplan-Meier and Cox proportional hazards models.

Results

p110α positivity was detected in 59.0% of specimens and showed significant correlation with histological grade (p = 0.034). Survival analysis revealed that p110α positivity was associated with worse OS (log-rank p = 0.008) and RFS (log-rank p = 0.0

SUBMITTER: Zong Z 

PROVIDER: S-EPMC12839064 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature