Prevalence and Imaging Correlates of Cerebral Diaschisis After Ischemic Stroke: A Systematic Review and Meta-Analysis.

ABSTRACT: Background/Objectives: Diaschisis, reduced neural activity, perfusion, and metabolism in structurally intact but anatomically connected regions, is a network-level consequence of focal brain injury. Despite the extensive literature, its prevalence across imaging modalities and diaschisis subtypes has not been systematically synthesized. This review aims to identify convergent evidence for diaschisis after ischemic stroke and clarify how its detection relates to neuroanatomical disconnection, clinical factors, and imaging methods. (PROSPERO: CRD420251017909). Methods: PubMed and Embase were searched through February 2025 for studies reporting quantitative measures of diaschisis using perfusion, metabolic, or functional imaging. Pooled prevalence and modality-specific estimates

SUBMITTER: Jia Q 

PROVIDER: S-EPMC12839182 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature