Highly Sensitive Detection and Discrimination of Cell Suspension Based on a Metamaterials-Based Biosensor Chip.

ABSTRACT: Metamaterials (MMs)-based terahertz (THz) biosensors hold promise for clinical diagnosis, featuring label-free operation, simple, rapid detection, low cost, and multi-cell-type discrimination. However, liquid around cells causes severe interference to sensitive detection. Most existing MMs-based cell biosensors detect dead cells without culture medium (losing original morphology), hindering stable, sensitive multi-cell discrimination. Here, a terahertz biosensor composed of a microcavity and MMs can be used to detect and discriminate multiple cell types within suspension. Its detection mechanism relies on cellular size (radius)/density in suspension, which induces effective permittivity (ε_eff) differences. By designing MMs' split rings with luxuriant gaps, the biosensor a

SUBMITTER: Chen K 

PROVIDER: S-EPMC12839188 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature