Technology-Critical Element Exposure Reveals Divergent Toxicity in Different Human Cells Despite Comparable Uptake.

ABSTRACT: The increasing use of Technology-Critical Elements (TCEs) in modern technology has led to widespread environmental release, raising questions about their biological effects, as emerging evidence suggests significant toxicity. We investigated the effects of three technology-critical elements, Indium oxide (In₂O₃), Lanthanum nitrate hexahydrate (La(NO₃)₃·6H₂O) and Cerium(III) nitrate hexahydrate (Ce(NO₃)₃·6H₂O), on human dermal fibroblasts (BJ) and hepatocarcinoma cells (HepG2), assessing their uptake, impact on viability, and induced cellular stress responses, quantified by markers of inflammation, oxidative stress, and membrane damage. Our results show a strong differential susceptibility: normal BJ fib

SUBMITTER: Magdas TM 

PROVIDER: S-EPMC12839252 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature