Response of Oral and Skin Keratinocytes to Oxidative Stress.

ABSTRACT: Oxidative stress caused by excessive reactive oxygen species (ROS) disrupts skin and oral epithelial homeostasis and contributes to skin aging, inflammation, periodontitis, and mucosal injury. As the principal defenders in both skin and oral mucosal tissues, keratinocytes are important responders to oxidative stress. However, most existing studies have examined skin or oral keratinocytes in isolation, with few comparative investigations of their tolerance, repair capacity, and antioxidant mechanisms under oxidative stress. In this study, we systematically compared immortalized oral keratinocytes (TIGK) and skin keratinocytes (HaCaT) under hydrogen peroxide (H₂O₂)-induced oxidative stress. Functional analyses, including cell survival, ROS accumulation, stress granule f

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12839278 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature