The Impact of Endpoint Definitions on Predictors of Progression in Active Surveillance for Early Prostate Cancer.

ABSTRACT: Background/Objectives: There is conflicting data on which factors predict progression events in active surveillance for early prostate cancer. Here, we explored the value of different clinicopathological variables and whether progression endpoint definitions impact predictive utility. Methods: Clinicopathological variables were extracted from the STRATified CANcer Surveillance (STRATCANs) prospective AS database and included biopsy features (core positivity, cancer core length, and percentage core involvement) and MRI features (Likert score, lesion size, and location), as well as baseline PSA density [PSAd] and Cambridge Prognostic Group (CPG). These were tested against AS endpoint definitions of (1) progression to ≥CPG3, (2) any pathological progression and two definitions f

SUBMITTER: Sandhu K 

PROVIDER: S-EPMC12839284 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature