Maternal Gestational Diabetes Mellitus Modulates Adipose Tissue Remodeling and CTRP6 Expression in a Depot- and Sex-Specific Manner in Mouse Offspring.

ABSTRACT: Objective: This study aimed to explore how maternal gestational diabetes mellitus (GDM) affects adipose tissue remodeling and the expression of C1q/TNF-related protein 6 (CTRP6) in offspring, with a focus on sex- and depot-specific differences. Methods: A GDM mouse model was established by feeding female C57BL/6J mice a high-fat diet (HFD) before and during pregnancy. Offspring were weaned onto standard chow or an HFD until 9 weeks of age. Metabolic phenotypes, adipose tissue morphology, and CTRP6 expression were assessed at weaning and adulthood. Results: GDM offspring exhibited increased adiposity and impaired glucose tolerance at weaning, with these effects persisting into adulthood in males. Maternal GDM reduced plasma CTRP6 levels in both sexes at weaning, but in

SUBMITTER: Wei X 

PROVIDER: S-EPMC12839290 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature