Synchrotron Radiation-Excited X-Ray Fluorescence (SR-XRF) Imaging for Human Hepatocellular Carcinoma Specimens.

ABSTRACT:

Background/objectives

Trace metals, including copper (Cu) and zinc, are associated with the development and prognosis of hepatocellular carcinoma (HCC). However, their interference with magnetic resonance imaging (MRI) limits their use as potential biomarkers. This study investigated the usefulness of Synchrotron Radiation-excited X-ray Fluorescence (SR-XRF) imaging in studying the distribution of trace metals in HCC.

Methods

This case-control study analyzed 33 specimens from 32 patients with HCC who underwent surgical resection (n = 29) or biopsy (n = 3) at Kobe University Hospital between December 1999 and November 2002. The findings of SR-XRF were compared with those of MRI and histopathology.

Results

SR-XRF provided two-dimensional mapping of trace m

SUBMITTER: Tsurusaki M 

PROVIDER: S-EPMC12839296 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature