Network Analysis to Identify MicroRNAs Involved in Alzheimer's Disease and to Improve Drug Prioritization.

ABSTRACT: Background: Advances in the understanding of molecular mechanisms of human diseases, along with the generation of large amounts of molecular datasets, have highlighted the variability between patients and the need to tailor therapies to individual characteristics. In particular, RNA-based therapies hold strong promise for new drug development, as they can be easily designed to target specific molecules. Gene and protein functions, however, operate within a highly interconnected network, and inhibiting a single function or repressing a single gene may lead to unexpected secondary effects. In this study, we focused on genes associated with Alzheimer's disease, a progressive neurodegenerative disorder characterized by complex pathological processes leading to cognitive decline and deme

SUBMITTER: Reyna A 

PROVIDER: S-EPMC12839359 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature