Proinsulin-Loaded Nanoparticles Suppress Insulitis and Induce Temporary Diabetes Remission.

ABSTRACT: Autoimmune type 1 diabetes (T1D) results from the failure of the physiologic regulatory mechanisms that are designed to maintain immune tolerance to pancreatic beta cells. Consequently, the design of strategies to restore tolerance to beta cell antigens is an attractive objective of translational research. We have designed ultrasmall nanoparticles (NPs) loaded with a proinsulin (PI) fusion protein and an agonist for the aryl hydrocarbon receptor (AhR), a transcription factor promoting tolerance induction by different immune cells. We report that a 4 week-treatment with these NPs in non-obese diabetic (NOD) mice starting at disease onset induces temporary and sometimes durable disease remission. Mechanistically, short-term NP treatment induces a rapid depletion of islet infiltrates with a d

SUBMITTER: Agapoff M 

PROVIDER: S-EPMC12839391 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature