Targeting Lung Cancer Cell Motility Using Microbeam Radiation Therapy.

ABSTRACT: Radiotherapy (RT) is currently among the standard treatments for lung cancer. However, in vitro studies have revealed that irradiation can increase lung cancer cell motility. This way, RT could potentially enhance the malignancy of solid tumors post-treatment, promoting metastasis. Therefore, there is a continued need to continue evolving RT modalities into safer and more effective treatments. The present study compares the impact of the broad beam (BB) and the spatially fractionated modality of microbeam radiation therapy (MRT) on the motility of A549 lung cancer cells. Our data corroborates previous findings that showed BB irradiation is a promoter of cell motility. For MRT, however, we observed a prevention of cellular migration. A significant reduction in NF-κB expression was ob

SUBMITTER: Dagkazanlı O 

PROVIDER: S-EPMC12839417 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature